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Downstream Processing: Chromatography
Learn the most suitable purification operation for your process and find out about new technologies on the horizon
26 - 29 November 2012
This module focuses on product purification and, through a series of lectures, case studies and a pilot plant session, will enable you to:
- Understand the principles of different methods of process chromatography, including Packed Bed, Monoliths, Expanded Bed, Counter Current and Simulated Moving Bed.
- Select the appropriate media for, and predict the performance of, chromatography separations upon scale-up.
- Assess the suitability of affinity separation as a product purification operation and gain awareness of advances in rational ligand design for difficult separations.
- Determine appropriate strategies for the maintenance of column and process hygiene.
- Consider how chromatography is changing at industrial scale, and which new technologies will have an impact in the future.
Who should attend?
This course is intended for engineers, chemists, biologists, biochemists and biotechnologists who are interested in the biochemical aspects of chromatography. Each concept and topic covered will be explained for the beginner - without assuming detailed prior knowledge.
Typically delegates are:
R&D scientists, engineers or managers who need to learn more about scale-up, scale-down and operation of chromatographic methods in a production environment.
Monday 26 November
• Introduction to Module
• Chromatography Fundamentals
• Models and Scale-Up
• High Throughput Chromatographic Bioseparations
• Pitfalls in the Scale-Up of Packed Bed Bioprocesses
Tuesday 27 November
• Pilot-Plant Studies: Chromatography
• Tailoring Media for Bioseparations
• Affinity Separation
• Design of Biomimetics for Affinity Separations
• Chromatography Practical Results
‘Future of downstream processing and the role of continuous chromatography’
Dr Marc Bisschops, Scientific Director, Tarpon Biosystems
Wednesday 28 November
• Process Hygiene and Column Maintenance
• Case Study: mAb-purification; issues in scaling-up to large process scale
• Alternative Approaches to Scaling up
• Design of Small Scale Columns for Ease of Scale-Up
• Simulated Moving Bed Chromatography for Biopharmaceutical Production
• Liquid - Liquid Chromatography
Thursday 29 November
• Process Scale Monoliths
• New Approaches to Process Scale Chromatography
• Case Study: Where and When to Apply Chromatography?
• Where Will Further Improvements in Chromatography Come From?
Previous Expert Speakers
Bo Forsberg, CMC
Rolf Frey, Bio-Rad Laboratories GmbH
Juergen Friedle, Atoll
Ian Garrard, Brunel University
Bjorn Hammarberg, ABD Life Sciences Ltd
Marko Jarc, BIA Separations
David Johnson, Pall Corporation
Markus Kellner, GE Healthcare
Hans May, Proxcys
Maarten Pennings, Batavia Bioservices
Marcel Raedts, Proxcys
Eric Thwaites, CMC Biologics A/S
Sharon Williams, ProMetic Biosciences
Jan Willem, Proxcys
A networking dinner will be held on the first evening.
The module costs £1600, with a £100 discount if you register and pay before 15 October
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Page last modified on 23 oct 12 15:42