Design of Experiments for Bioprocess Optimisation
Learn how experimental design techniques can be used to rapidly understand and optimise bioprocess performance.
12 - 14 March 2012
This module shows practitioners how experimental design techniques can be used to rapidly understand and optimise bioprocess performance. It provides managers with methods to ensure the whole bioprocess sequence is operating robustly and development budgets are used effectively. Training is focused on the hands on use of DoE software rather than underlying statistics. Bioprocess case studies, supported by a series of introductory and expert lectures will enable you to:
- Generate appropriate experimental designs within fixed research budgets and timescales.
- Ensure analytical methods can be validated and provide reliable data for process evaluation.
- Rapidly screen and optimise different fermentation media and operating conditions.
- Obtain the highest yield of active product throughout your downstream process sequence.
Who should attend?
The course is designed for all those involved in bioprocess development and optimisation including:
- Bioprocess applications specialists
- Hands-on bioprocess scientists and engineers
- Research managers and consultants
Programme
Monday 12 March
• Introduction to Module and Design of Experiments
• Introduction to Experimental Design Techniques and Software
• Case Studies: Analytical Method Validation (OFAT vs DoE)
• Industrial Analytical Method Validation using DoE
Tuesday 13 March
• Screening and Optimisation of Microbial Fermentations
• Case Study: Fermentation Process Screening
• Case Study: Fermentation Process Optimisation and Scale-Up
• Application of DoE in Mammalian Cell Culture Process Development
Wednesday 14 March
• Case Study: Primary Product Recovery by Microfiltration
• Optimisation and Validation of Chromatographic Steps for Antibody Purification
• Protein Refolding, Stabilisation and Formulation
• Bioprocess Management and Quality Benefits of DoE
• Discussion Forum
A social networking event will be held for delegates and speakers
Module Leader
Gary Lye, UCL
Teaching Staff
Frank Baganz, UCL
Daniel Bracewell, UCL
Paul Dalby, UCL
Previous Expert Speakers
Phil Borman GSK
Craig Gershater Cambridge Bioprocess Management
Ian Macpherson PRISM Training and Consultancy
Jim Mills Cantabio
A social networking event will be held for delegates and speakers
The module costs £1300, with a £100 discount if you register and pay before 26 February.
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Page last modified on 30 sep 11 11:59
