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Design of Experiments for Bioprocess Optimisation
Learn how experimental design techniques can be used to rapidly understand and optimise bioprocess performance.
11 - 13 March 2013
This module shows laboratory scientists and engineers how experimental design techniques can be used to rapidly understand and optimise bioprocess performance. It provides managers with insights on how experimental design and small scale experimental models can underpin Quality by Design (QbD) approaches. Training is focused on the hands on use of DoE software rather than underlying statistics. Bioprocess case studies, supported by a series of introductory and expert lectures will enable you to:
• Generate appropriate experimental designs within fixed research budgets and timescales.
• Ensure analytical methods can be validated and provide reliable data for process evaluation.
• Rapidly screen and optimise different fermentation media and operating conditions.
• Obtain the highest yield of active product throughout your downstream process sequence.
• Understand the relationship between DoE and QbD
Who should attend?
The course is designed for all those involved in bioprocess development and optimisation including:
- Bioprocess applications specialists
- Hands-on bioprocess scientists and engineers
- Research managers and consultants
Monday 11 March
• Introduction to Module and Design of Experiments
• Introduction to Experimental Design Techniques and Software
• Case Studies: Analytical Method Validation (OFAT vs DoE)
• Industrial Analytical Method Validation using DoE
Tuesday 12 March
• Screening and Optimisation of Microbial Fermentations
• Case Study: Fermentation Process Screening
• Case Study: Fermentation Process Optimisation and Scale-Up
• Application of DoE in Mammalian Cell Culture Process Development
Wednesday 13 March
• Case Study: Primary Product Recovery by Microfiltration
• Optiisation and Validation of Chromatographic Steps for Antibody Purification
• Protein Refolding, Stabilisation and Formulation
• Bioprocess Management and Quality Benefits of DoE
Gary Lye, UCL
Frank Baganz, UCL
Daniel Bracewell, UCL
Paul Dalby, UCL
Previous Expert Speakers
Phil Borman, GSK
Craig Gershater, Cambridge Bioprocess Management
Ian Macpherson, PRISM Training and Consultancy
Jim Mills, Cantabio
Sunil Chhatre, Tap Biosystems
A social networking event will be held for delegates and speakers
The module costs £1300, with a £100 discount if you register and pay before 28 January.
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Page last modified on 01 aug 12 14:16