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Research projects

A UCL Biochemical Engineering researcher

A list of current research projects, all of which are collaborations with industrial partners.

2013/2014

Project title Researcher Supervisor(s) 
Gene Delivery Vector Platforms for Novel Gene Therapies Ali Sadfer Dr Darren Nesbeth, Prof Chris Mason
Real-Time Visualisation of Protein Self-Assembly Hasan Alkaseem Dr Bart Hoogenboom, Dr Daniel Bracewell
Novel Chassis for Engineered Pathways Aisha Asra Prof John Ward
   Ruchika Bandekar  Prof Gary Lye
Financial and Operational Perspectives of Cell Therapy Bioprocessing  Tania Chilma  Dr Suzanne Farid, Dr Sofia Simaria
Optimisation of Antibody Expression and Recovery from High Cell Density Microbial Fermentations at the Microwell Scale  Mary Lunson  Prof Gary Lye
Understand cell lysis in fermentation and primary recovery by online viscosity sensor  Joseph Newton  Dr Yuhong Zhou
Bioabsorbable tracheal scaffolds for clinical application  Toby Proctor Prof Chris Mason, Dr Farlan Veraitch 
S-Layer Lattice Assembly for Biotechnological Applications  Bouran Sohrabi Dr Stefan Howorka, Prof Gary Lye 
Leveraging High-Throughput Purification Data using Advanced Visualisation and Predictive Tools  Christos Stamatis Dr. Suzanne Farid, Prof Nigel Titchener-Hooker
Nanofibre Adsorbents as a Purification Platform for Emerging Viral Vectores and Vaccines  Jordan Turnbull  Dr Daniel Bracewell

2012/2013

Title Researcher Supervisor(s) 
An Integrated Scale-Down Platform for the Extraction and Recovery of Periplasmically Expressed Complex Molecules from E.Coli Asma Ahmad Dr Martina Micheletti, Prof Eli Keshavarz-Moore 
Scalable Production of Tissue Engineered Microunits for Bone Regeneration Using Bioactive Glass Microshperes and Dynamic Culture Conditions David De Silva Thompson Dr Ivan Wall, Dr Martina Micheletti 
Primary recovery of high value products from high cell density harvests Anne Marie De Villiers Dr Tarit Mukhopadhyay, Prof Nigel Titchener-Hooker 
Rapid Fermentation Process Optimisation using State-of-the-Art Mini Bioreactors and Advanced Modelling Approaches Aaron Erbas Dr Frank Baganz, Prof Gary Lye 
Induced Pluripotent Stem Cell Processing for Drug Discovery Platforms and Cell therapy Products: Process Economics Michael Jenkins Dr Suzanne Farid, Dr Sofia Simaria 
Evaluation of Biological and Process Options for Alkaline Biooxidations Johannes Kolmar Dr Frank Baganz 
Developemtnt of Synthetic Shear Tracer Particles for Scale-Down Models of Continuous Centrifugation and Density Gradient Ultra-Centrifugation and a Mimic of Various Vaccine Candidates Beatrice Melinek Dr Tarit Mukhopadhyay, Dr Daniel Bracewell
Understanding Protease Contaminants during Biopharmaceutical Manufacture from CHO Cell Culture Damiano Migani Dr Daniel Bracewell, Prof Mark Smales 
A Comparison between Aqueous Two-Phase Extraction and Chromatography for the Separation of Novel Biopharmaceuticals using High Throughput Process Development (HTPD) Methodologies Nehal Patel Dr Daniel Bracewell, Dr Eva Sorensen
Rapid Materialisation of Synthetic Biology Products James Rutley Prof Gary Lye, Dr Martina Micheletti 
Purification of Recombinnat Vaccinia Viruses for Cancer Therapy and Cancer Vaccine using Monolthic Column Technology David Vincent Dr Yuhong Zhou, Dr Daniel Bracewell 

2011/2012

Title Researcher Supervisor(s)
Novel Strategies for Early Downstream Processing of High Density Mammalian Cell Culture Georgina Espuny Garcia Del Real Dr Daniel Bracewell, Prof Michael Hoare 
Scale-Down Characterisation and Modelling of Harvest Operations in Cell Culture Processes  Joseph Allen Prof Nigel Titchener-Hooker, Dr Suzanne Farid
Developing a Novel and Cost-Effective Method of Purification or Therapeutic Proteins using Affinity Tags Adam McInally Prof Michael Hoare, Dr Paul Dalby
Engineering Characterisation of Cylindrical Shaken Bioreactors for Improved Cell Culture Process Development and Scale Up Gregorio Rodriguez Dr Martina Micheletti, Dr Andrew Ducci (UCL Chemical Engineering)
Cell and Protein Engineering Strategies to Maximise the Recovery and Dimerisation of a Biotherapeutic Antibody-Enzyme Fusion Protein Produced in E.Coli Desmond Schofield Dr Darren Nesbeth, Dr Kerry Chester (UCL Oncology) 
Applications of an Ultra-Rapid Next-Gen  Thermocycler in PCR-based Bioprocess Monitoring Alex Templar Dr Darren Nesbeth, Prof Eli Keshavarz-Moore 
An Upstream Platform for the Production of High Grade Heterologous Proteins in Pichia Pastoris Ben Weil Dr Darren Nesbeth, Dr Daniel Bracewell 

2010/2011

Title Researcher  Supervisor(s) 
Scale Down and Optimisation of a Novel Second Generation Bioethanol Process Neil Conroy Prof Gary Lye, Dr Paul Dalby 
Microscale Methods for the Rapid Analysis of Antibiotic Compound Libraries and Systematic Downstream Process Design Haroon Khan Prof Gary Lye, Dr Nicholas Szita 
An Ultra Scale-Down Tool for the Predicitve Design of a Filtration Procedure for Preparation of Human Cell Therapies Chris Longster Prof Michael Hoare, Dr Ivan Wall 
Engineering Characterisation of Single-Use Wave-Type Bioreactors for Improved Cell Culture Process Development and Scale-Up Douglas Marsh Prof Gary Lye, Dr Martina Micheletti 
Design and Evaluation of an Internally Radiating Photobioreactor for Generic Application in the Algal Production of Biofuels, Biorenewable Chemicals and Biopharmaceuticals Kane Miller Prof Gary Lye, Dr Martina Micheletti 
High Throughput Protein Precipitation for Monoclonal Antibody Purification Chris Morris Prof Nigel Titchener-Hooker, Dr Paul Dalby 
Streamlined Purification and Process Understanding of Polysaccharide Vaccine Components Aaron Noyes Dr Tarit Mukhopadhyay, Prof Nigel Titchener-Hooker 
Towards a More Efficient Platform for Inclusion Body Processing from Engineered E.Coli Aminat Omotosho Prof Eli Keshavarz-Moore, Dr Gareth Mannall 
Novel Primary Recovery Srategies for High Cell Density Mammalian Cell Daria Popova Prof Nigel Titchener-Hooker, Dr Suzanne Farid 
Non-Geometric Scale Up of Chromatographic Separations of Biopharmaceuticals Jayan Senaratne Prof Nigel Titchener-Hooker, Dr Daniel Bracewell 
Controlling Early Cell Human Embryonic Stem Cell Fate with Growth Factors and Oxygen Concentration Vishal Sharma Dr Farlan Veraitch, Dr Nicholas Szita 
Production Planning across Multi-Site, Multi-Product Biopharmaceutical Plants under Uncertainty Cyrus Siganporia Dr Suzanne Farid, Dr Lazaros Papageorgiou 

2009/2010

Title Researcher  Supervisor(s) 
Improving Bone Marrow Stem Cell Therapy for Cardiac Repair Owen Bain Dr Ivan Wall, Prof Chris Mason
Incorporation of Developability into Cell Line Selection: Creation of a Simplified High-Throughput Small-Scale Model for a mAb Manufacturing Process John Betts Prof Gary Lye, Dr Frank Baganz 
Small Scale, High Throughput Process Development with a Focus on Novel Therapeutic Proteins Alex Chatel Prof Mike Hoare, Prof Nigel Titchener-Hooker 
Process Modelling Approaches to Biological Complexity in the Production of Therapeutic Proteins Edward Close Dr Daniel Bracewell, Dr Eva Sorensen 
Microscale Characterisaton of a Manufacturing Route for Lentiviral Vectors Heather Guy Dr Tarit Mukhopadhyay, Prof Gary Lye 
Measurement of Protein Self-Association Behaviour as a Determinant of Aggregation in Bioprocessing Krisztina Kovacs-Schreiner Dr Daniel Bracewell, Prof Michael Hoare 
A Microscale Purification Platform for the Study of Fusion Protein Recovery Eduardo Lau Prof Michael Hoare, Dr Paul Dalby 
Dental Stem Cells for Tooth Regeneration and Repair Yvonne Pang  Dr Ivan Wall, Prof Chris Mason 
Scale-Up of Tissue Engineering Trachea using Adult Stem Cells Leanne Partington Dr Ivan Wall, Prof Chris Mason
The Bioprocessing of Human Embryonic Stem Cells to Treat Blindness Iwan Thomas Roberts Prof Chris Mason, Prof Peter Coffey
Investigation of IgG Aggregate Formation in Biopharmaceutical Processes; A Study of the Location and Mechanism of Aggregation Roumteen Tavakoli-Keshe Dr Daniel Bracewell, Prof Nigel Titchener-Hooker
Scaling Omnicyte (Adult Stem Cells) Therapy for Safe, Effective and Affordable Clinical Use. Characterisation of miRNAs for Stem Cell Expansion and Regenerative Medicine John Thwaites Dr Ivan Wall, Prof Chris Mason 
Pre-Formulation Screening: High Throughput Tools to Formulate dABs and Predict Stability Profiles Udofoyo Uye Dr Paul Dalby, Prof Michael Hoare 

Page last modified on 29 oct 13 15:44