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Dr. Olatomirin Kolade
Post-Doctoral Research Associate
Phone +44 (0)207 679 3136
PhD Chemistry, University of East Anglia
MSc Crystallography, Birkbeck, University of London
Professional Appointments, Honours and Awards
Post-Doctoral Research Associate, UCL (2010 to date)
Process Development Scientist, HPA, Porton Down (2009- 2010)
Principal Scientist, Emergent Biosolutions (2007-2009)
Post-Doctoral Research Scientist, Michigan State University, USA (2002-2004)
Post-Doctoral Research Associate, University of East Anglia (1998-2002)
Ola’s research explores non-native protein aggregation during the latter stages of the manufacturing process.
The marginal stability of proteins has undesirable effects during bioprocessing operations; elevating their tendency to unfold and transition to the aggregated state. Aggregates can be generated in the bulk solution or during adsorption to an interface. Fill-finish operations present a particular challenge because of the range of surfaces (e.g. mixing tanks, probes, pumps, tubing, syringes and glass vials) encountered by the drug product.
Our work is concerned with understanding the factors that influence aggregation at the solid-liquid interface in these latter stages. Control of this phenomenon ensures that appropriate measures can be taken to limit the impact on product quality and efficacy.
The PI of this project is Dr. Daniel Bracewell and this work is being conducted in collaboration with GlaxoSmithKline.
Teaching and Training Activities - none
In vitro characterization of the cysteine-rich capping domains in a plant leucine rich repeat protein. O. O. Kolade, V. A. Bamford, G. Ancillo, J. Jones, P. Vera, and A. Hemmings. Biochim. Biophys. Acta. 1764:1043-53 (2006)
Use of dominant-negative HrpA mutants to dissect Hrp pilus assembly and type III secretion in Pseudomonas syringae pv. tomato DC3000. Y. H. Lee, O. O. Kolade, K. Nomura, D. N. Arvidson and S. Y. He. J. Biol. Chem. 280: 21409-21417 (2005).
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