UCL DEPARTMENT OF BIOCHEMICAL ENGINEERING

Biochemical Engineering

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Sally Hassan

Dr. Sally Hassan
Postdoctoral Research Associate
Email: sally.hassan@ucl.ac.uk
Tel: Tel: +44 (0)20 7679 7745

Background
MEng in Biochemical Engineering with Bioprocess Management (First class honours), University College London, 2004
PhD in Biochemical Engineering, University College London, (collaboration with St. George’s, University of London, and the University of Birmingham). 2008
Postdoctoral Research associate- (collaboration between Department of Biochemical Engineering and the Institute of Structural and Molecular Biology at University College London)
Industrial Experience: Research and Development Scientist in Purification Development at Lonza Biologics (2010-2012)

Research Interests
My research interest is in the bioprocessing of complex macromolecules with therapeutic promise. This includes monoclonal antibody (mAb) production in transgenic tobacco plants and scalable purification of mAbs or recombinant proteins from mammalian cell culture. I have also carried out research to facilitate downstream processing by genetic manipulation of a model plasmid DNA product and optimal small-scale fermentation. My current research involves developing a process economics model for cell therapy manufacturing using a computer-based decisional support tool.

Selected publications:
Hassan S, Colgan R, Paul MJ, Atkinson CJ, Sexton AL, van Dolleweerd CJ, Keshavarz-Moore E, Ma JK. 2012 Recombinant monoclonal antibody yield in transgenic tobacco plants is affected by the wounding response via an ethylene dependent mechanism. Transgenic Res. (Epub ahead of print)

Colgan R, Atkinson CJ, Paul M, Hassan S, Drake PM, Sexton AL, Santa-Cruz S, James D, Hamp K, Gutteridge C, Ma JK. 2010 Optimisation of contained Nicotiana tabacum cultivation for the production of recombinant protein pharmaceuticals. Transgenic Res.;19(2):241-56.

Hassan S, van Dolleweerd CJ, Ioakeimidis F, Keshavarz-Moore E, Ma JK. 2008
Considerations for extraction of monoclonal antibodies targeted to different subcellular compartments in transgenic tobacco plants.
Plant Biotechnol J.

Hassan S, Liu W, Ma JK, Thomas CR, Keshavarz-Moore E. 2008. Characterization of mechanical properties of transgenic tobacco roots expressing a recombinant monoclonal antibody against tooth decay. Biotechnol Bioeng.;100(4):803-9.

Hassan S, Titchener-Hooker N, Willoughby N. 2005. Determining particle density distribution of expanded bed adsorbents. Biotechnol Bioeng.;92(5):659-63.

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