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Lecturer in Biochemical Engineering
Tutor MEng Biochemical Engineering with Chemical Engineering
Year 2 Tutor
Schools Outreach: Royal Academy of Engineering Headstart
Phone: +44 (0)20 7679 3815
Fax:+44 (0)20 7916 3943
PhD Electrical and Electronic Engineering, Imperial College, University of London (1994)
MSc Automatic Control Engineering, Beijing Institute of Technology (1986)
BSc Automatic Control Engineering, Beijing Institute of Technology (1983)
Professional Appointments, Honours and Awards
Research Fellow, then Senior Research Fellow in the Department of
Biochemical Engineering, University College London (1994-1999)
Assistant Professor, Lecturer at Shenyang Institute of Technology (1986-1990)
Yuhong Zhou leads the bioprocess modelling research in the Innovative Manufacturing Research Centre (IMRC) in Bioprocessing. The research in this area has played an important role in the faster creation of biomanufacturing processes at lower cost. Collaborating with Prof. Nigel Titchener-Hooker, Prof. Mike Hoare and Dr. Dan Bracewell in the IMRC programme, her modelling research is integrated closely with ultra scale-down and microwell techniques to develop Intelligent Design of Experiment (IDoE) methods for the rapid creation of whole bioprocesses. The research also focuses on the development of fast analytical tools such as Windows of Operation and Robust Operation Strategies for the whole bioprocess which aims to provide industry with a new opportunity to more readily embrace bioprocess optimization tools. Collaboration with one of the IMRC industrial partners (BioPharm Services) has led to a tool for assessing the solutions in chromatographic process design and operation for large-scale manufacture.
Yuhong’s research interest in plant-wise management of bioprocessing manufacture has led her to create agent-based methods for efficient communication and real-time decision-making to improve the performance of manufacturing processes by collaborating with Prof. Nigel Titchener-Hooker and Prof. Gary Montague and Dr Jarka Glassey at Newcastle University . S he is also interested in the development of bioprocess knowledge base through collaboration with Dr Anthony Hunter in the UCL Computer Science department.
Collaborating with Prof. John Ward (Biochemistry and Molecular Biology) and Dr. Frank Baganz, her research in Metabolic Network Modelling strives to obtain an enhanced understanding of the metabolism and cellular functions by metabolic modelling and simulation of a whole cell. Based on the metabolic flux analysis studies, targets will be identified for pathway manipulation and the required biological changes determined in order to achieve good performance in fermentation.
Funding for the above research has come from the UK EPSRC and BBSRC and a range of company collaborators.
Teaching and Training Activities
Yuhong’s teaching activities span all years of the various undergraduate and postgraduate degree programmes in the department. These include Computer-Aided Bioprocess Engineering, Monitoring and Control in Fermentation Processes (in Biochemical Reactor Engineering), Mass Balance in Primary Recovery (in Introduction to Biochemical Engineering) and Integrated Biochemical Engineering Design. She also co-ordinates a wide range of practicals training activities in the department. She is the module leader for MBI Primary Recovery module.
Together with Prof Nigel Titchener-Hooker she is responsible for managing the progress of all doctoral programmes in the department.
*If you would like further information on any of these publications or news of related research, please contact firstname.lastname@example.org
Chhatre S., Francis R., Newcombe A.R., Zhou Y., Titchener-Hooker N.J., King, J. and Keshavarz-Moore, E. 2007. Global sensitivity analysis for the determination of parameter importance in the chromatographic purification of polyclonal antibodies. Journal of Chem Tech Biotech. Published online 11 Dec. doi:10.1002/jctb.1801
Tran, R., Joseph, J.R., Bracewell, D., Zhou, Y., Titchener-Hooker, N.J,. 2007. A framework for the prediction of scale-up when using compressible chromatographic packings. Biotech Progress. 23(2), 413-422. doi: 10.1021/bp060303i
King, J.M.P., Titchener-Hooker, N.J. and Zhou, Y . 2007. Ranking bioprocess variables using global sensitivity analysis: A case study in centrifugation. Bioprocess and Biosystem Eng. 30(2), 123-134. doi:10.1007/s00449-006-0109-5
Joseph, J., Sinclair, A., Titchener-Hooker, N.J. , Zhou, Y. 2006. A framework for assessing the solutions in chromatographic process design and operation for large-scale manufacture, Journal of Chemical Tech Biotech. 81, 1009-1020. doi:10.1002/jctb.1508
Lakhdar, K., Savery, J., Zhou, Y., Titchener-Hooker, N.J., Papargeougiou, L. 2005. Medium term planning of biopharmaceutical manufacture using mathematical programming. Biotech Progress. 21, 1478-1489. doi: 10.1021/bp0501571
Mustafa, M.A., Washbrook, J., Lim, J., Zhou, Y., Titchener-Hooker, N.J., Morton P., Berezenko S. and Farid, S. 2004. A software tool to assist business-process decision making in the biopharmaceutical industry. Biotech Progress. 20(4); 1096-1102. doi: 10.1021/bp034377v
Lim, A.C., Zhou, Y., Washbrook, J., Sinclair, A., Fish, B., Francis, R., Titchener-Hooker, N.J., Farid, S.S. 2005. Application of a decision-support tool to assess pooling strategies in perfusion culture processes under uncertainty. Biotech Progress. 21(4), 1231 – 1242. doi: 10.1021/bp049578t
King, J., Griffiths, P., Zhou, Y., Titchener-Hooker, N.J. 2004. Visualising Bioprocess using 3D-Windows of operation. Journal of Chem Tech Biotech. 79, 518-525. doi:10.1002/jctb.1015
Lim, A.C., Zhou, Y., Washbrook, J., Titchener-Hooker, N.J., Farid, S. 2004. A decisional-support tool to model the impact of regulatory compliance activities in the Biomanufacturing industry. Computers and Chemical Engineering. 28, 727-735. doi: 10.1016/j.compchemeng.2004.02.013
Zhou, Y. and Titchener-Hooker, N.J. 2003. The application of a Pareto optimisation method in the design of an integrated bioprocess . Bioprocess and Biosystems Eng. 25, 349-355. doi:10.1007/s00449-003-0318-0
Ngiam S.H., Bracewell D.G., Zhou Y., and Titchener-Hooker, N.J. 2003. Quantifying Process Tradeoffs in the Operation of Chromatographic Sequences. Biotech Progress. 19(4), 1315 – 1322. doi: 10.1021/bp034039u
Ngiam, S.H., Zhou, Y., Turner, M.K., Titchener-Hooker, N.J. 2001. A graphical method for the calculation of chromatographic performance in representing the trade-off between purity and recovery. Journal of Chromatography A. 937, 1-11. doi:10.1016/S0021-9673(01)01299-7
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