Ivan Wall
Lecturer in Regenerative Medicine Bioprocessing (Visiting Professor Dankook University, Korea)
Undergraduate Admissions Tutor
Schools Outreach: Nuffield Science Bursary Scheme
Phone: +44 (0)20 7679 3918
Fax: +44 (0)20 7209 0703
i.wall@ucl.ac.uk
Education
PhD Cell Biology, Cardiff University (2006)
MPhil Wound Healing, University of Wales College of Medicine (2002)
BSc. (Hons) Anatomical Science, Cardiff University (2000)
Professional Appointments, Honours and Awards
Member of the Tissue and Cell Engineering Society
Scientific Advisor, Doctors Academy (www.doctorsacademy.org)
Post-doctoral Research Associate, UCL Institute of Ophthalmology (2007-2009)
Post-doctoral Research Associate, UCL Eastman Dental Institute (2005-2007)
Research Interests
Ivan’s research interests focus on the regenerative potential of stem cells for treating a range of diseases. Life expectancy in Western society is continually improving but there is also a gradual increase in age-related health problems in these people. The decline in healthy physiological function makes us more susceptible to a wide variety of degenerative disorders that affect neurological, cardiovascular and musculoskeletal systems, to name a few.
Throughout the adult body, stem cell populations maintain and replenish local tissues. Our aim is to use these cells to restore function to diseased or damaged tissues. Ivan’s research interests encompass two main themes:
The effects of the physical bioprocessing environment (including substrate composition, mechanical force and bioprocessing forces) on regenerative cell responses
Defining and exploiting adult stem cell niche signals for activation of therapeutic stem cell populations
In addition, Ivan co-ordinates the research activity for a cohort of students for the London Regenerative Medicine Initiative, founded by Prof Chris Mason and funded by the UK Stem Cell Foundation and EPSRC.
Current research collaborations include:
Prof Anthony Mathur (Barts and the London Hospital) - Translation of bone marrow-derived cell therapies for routine treatment of cardiac disease
Prof Martin Birchall (UCL Hospitals) & Dr Mark Lowdell (Royal Free Hospital) - Scale out methods for tissue-engineered airways using adult mesenchymal stem cells
Prof Paul Sharpe (Kings College London) - Adult stem cells for tooth regeneration
Dr Maeve Cauldwell (University of Bristol) – Effect of hypoxia on derivation of functional neuronal subsets
Dr. Maria Retzepi & Prof Nikolaos Donos (UCL Eastman Dental Institute) - Bone regeneration strategies in health and disease
Prof Mike Hoare (UCL Dept of Biochemical Engineering) - Effect of capillary shear stress on differentiation potential of stromal progenitor cells
Teaching and Training Activities
Ivan teaches cell biology and biochemistry to undergraduate (BEng/MEng) and postgraduate (MSc) biochemical engineering students. He also lectures on the MBI in Mammalian Cell Processing and also co-ordinates numerous outreach activities including the Nuffield Foundation science bursaries and schools educational events.
Selected Publications
*For further information on the publications presented below, please contact Ivan at i.wall@ucl.ac.uk
Manuscripts published and in press
Hwang JY, Shin US, Yoon IK, Jang WC, Wall IB, Kim H-W. 2012. Biofunctionalized carbon nanotubes in neural regeneration: mini-review. Nanoscale accepted
Partington L, Mordan N, Kim H-W, Mason C, Knowles JC, Lowdell M, Birchall MA, Wall IB. 2012. Biochemical changes caused by decellularization may compromise mechanical integrity of tracheal scaffolds. Acta Biomaterialia in press (available online) DOI: 10.1016/j.actbio.2012.10.004
Badger JL, Byrne ML, Veraitch FS, Mason C, Caldwell MA, Wall IB. 2012. Hypoxic culture of human pluripotent stem cell lines is permissible using mouse embryonic fibroblasts. Regenerative Medicine in press 7(5):675-683 DOI: 10.2217/rme.12.55
Guedes JC, Park JH, Lakhkar N, Kim HW, Knowles JC, Wall IB. 2012. TiO2-doped phosphate glass microcarriers: a stable bioactive substrate for expansion of adherent mammalian cells. Journal of Biomaterials Applications in press (available online) DOI: 10.1177/0885328212459093
Park J-H, Perez R, Jin G-Z, Choi S-J, Kim H-W, Wall I. 2012. Microcarriers designed for cell culture and tissue engineering of bone. Tissue Engineering Part B accepted
Lee J-H, Tsendsuren T, Park J-H, Wall I, Kim H-W. 2012. Providing osteogenesis conditions to mesenchymal stem cells using bioactive nanocomposite bone scaffolds. Materials Science and Engineering C accepted
Lakhkar NJ, Park JH, Mordan NJ, Salih V, Wall IB, Kim HW, King SP, Hanna JV, Martin RA, Addison O, Mosselmans JFW, Knowles JC. 2012. Titanium phosphate glass microspheres for bone tissue engineering. Acta Biomaterialia 8(11):4181-90 DOI: 10.1016/j.actbio.2012.07.023
Lakhkar NJ, Lee IH, Kim HW, Salih V, Wall I, Knowles JC. 2012. Bone formation controlled by biologically relevant inorganic ions: Role and controlled delivery from phosphate-based glasses. Adv Drug Deliv Rev in press DOI: 10.1016/j.addr.2012.05.015
Yu HS, Jin GZ, Won JE, Wall I & Kim HW. 2012. Macrochanneled bioactive ceramic scaffolds in combination with collagen hydrogel: A new tool to bone tissue engineering. J Biomed Mater Res Part A in press DOI: 10.1002/jbm.a.34163
Jin GZ, Kim JH, Park JH, Choi SJ, Kim HW & Wall I. 2012. Performance of evacuated calcium phosphate microcarriers loaded with mesenchymal stem cells within a rat calvarium defect. J Mater Sci: Mater Med in press DOI: 10.1007/s10856-012-4646-y
Park HS, Lee HY, Seo JA, Kim HW, Wall IB, Gong MS & Knowles JC. 2012. Synthesis of elastic biodegradable polyesters of ethylene glycol and butylene glycol from sebacic acid. Acta Biomater in press¬ E-pub DOI: 10.1016/j.actbio.2012.04.026
Yun YR, Jang JH, Jeon E, Kang W, Lee S, Kim HW & Wall I. 2012. Administration of Growth Factors for Bone Regeneration. Regenerative Medicine 7(3):369-385 DOI 10.2217/rme.12.1
Oh SA, Lee HY, Lee JH, Kim TH, Jang JH, Kim HW & Wall I. 2012. Collagen Three-Dimensional Hydrogel Matrix Carrying Basic Fibroblast Growth Factor for the Cultivation of Mesenchymal Stem Cells and Osteogenic Differentiation. Tissue Eng Part A 18(9-10):1087-1100 DOI: 10.1089/ten.tea.2011.0360
Brindley D, Moorthy K, Lee J-H, Mason C, Kim H-W & Wall I. 2011. Bioprocess Forces and Their Impact on Cell Behavior: Implications for Bone Regeneration Therapy. J Tiss Eng. Online article ID 620247, 13 pages DOI: 10.4061/2011/620247
Mulhall, H, Patel, M, Alqahtani, K, Mason, C, Lewis, MP and Wall, I. 2011. Effect of capillary shear stress on recovery and osteogenic differentiation of muscle-derived precursor cell populations. J Tissue Eng Regen Med 5(8):629-635 DOI: 10.1002/term.355
Ivanovski, S, Hamlet, S, Retzepi, M, Wall, I and Donos, N. 2011. Transcriptional profiling of "guided bone regeneration" in a critical-size calvarial defect. Clin Oral Implants Res 22(4):382-389 DOI: 10.1111/j.1600-0501.2010.02104.x
Donos, N, Retzepi, M, Wall, I, Hamlet, S and Ivanovski, S. 2011. In vivo gene expression profile of guided bone regeneration associated with a microrough titanium surface. Clin Oral Implants Res 22(4):390-398 DOI: 10.1111/j.1600-0501.2010.02105.x
Patel, M, Mulhall, H, Al-Quatani, K, Lewis, M and Wall, I. 2011. Muscle-derived precursor cells isolated on the basis of differential adhesion properties respond differently to capillary flow. Biotechnol Lett 33(7):1481-1486 DOI: 10.1007/s10529-011-0570-3
Enoch, S, Peake, MA, Wall, I, Davies, L, Farrier, J, Giles, P, Kipling, D, Price, P, Moseley, R, Thomas, D and Stephens, P. 2010. 'Young' oral fibroblasts are geno/phenotypically distinct. J Dent Res 89(12):1407-1413 DOI: 10.1177/0022034510377796
Wall, IB, Bhadal, N, Broad, S, Whawell, SA, Mudera, V and Lewis, MP. 2009. Force generation and protease gene expression in organotypic co-cultures of fibroblasts and keratinocytes. J Tissue Eng Regen Med 3(8):647-650 DOI: 10.1002/term.206
Wall, I, Donos, N, Carlqvist, K, Jones, F and Brett, P. 2009. Modified titanium surfaces promote accelerated osteogenic differentiation of mesenchymal stromal cells in vitro. Bone 45(1):17-26 DOI: 10.1016/j.bone.2009.03.662
Enoch, S, Wall, I, Peake, M, Davies, L, Farrier, J, Giles, P, Baird, D, Kipling, D, Price, P, Moseley, R, Thomas, D and Stephens, P. 2009. Increased oral fibroblast lifespan is telomerase-independent. J Dent Res 88(10):916-921 88/10/916 [pii] DOI: 10.1177/0022034509342979
Wall, IB, Moseley, R, Baird, DM, Kipling, D, Giles, P, Laffafian, I, Price, PE, Thomas, DW and Stephens, P. 2008. Fibroblast dysfunction is a key factor in the non-healing of chronic venous leg ulcers. J Invest Dermatol 128(10):2526-2540 DOI: 10.1038/jid.2008.114
Bhadal, N, Wall, IB, Porter, SR, Broad, S, Lindahl, GE, Whawell, S and Lewis, MP. 2008. The effect of mechanical strain on protease production by keratinocytes. Br J Dermatol 158(2):396-398 DOI: 10.1111/j.1365-2133.2007.08341.x
Lygoe, KA, Wall, I*, Stephens, P and Lewis, MP. 2007. Role of vitronectin and fibronectin receptors in oral mucosal and dermal myofibroblast differentiation. Biol Cell 99(11):601-614 DOI: 10.1042/BC20070008 *joint first author
Stephens, P, Wall, IB, Wilson, MJ, Hill, KE, Davies, CE, Hill, CM, Harding, KG and Thomas, DW. 2003. Anaerobic cocci populating the deep tissues of chronic wounds impair cellular wound healing responses in vitro. Br J Dermatol 148(3):456-466
Wall, IB, Davies, CE, Hill, KE, Wilson, MJ, Stephens, P, Harding, KG and Thomas, DW. 2002. Potential role of anaerobic cocci in impaired human wound healing. Wound Repair Regen 10(6):346-353
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