Farlan Veraitch
Senior Lecturer in Biochemical Engineering
Undergraduate Tutor
Phone: + 44 (0)20 7679 2648
Fax: + 44 (0)20 7209 0703
f.veraitch@ucl.ac.uk
Education
PhD Biochemical Engineering, The University of Birmingham
MEng Chemical with Biochemical Engineering, University College London
Research Interests
Farlan’s research focuses on the development of robust, reproducible and cost effective production processes in the emerging field of cell therapy. His team are establishing novel processing technologies which will underpin the commercialisation of these types of products. Their work uses a “whole bioprocessing” methodology pioneered at UCL to ensure that new production process are considered as whole rather than individual operations in isolation. Using pluripotent stem cells as a model system Farlan’s group is developing new methods for the majority of steps involved in the production of cellular therapies. Current projects include the application of bioprocessing methodologies to (i) the expansion of pluripotent stem cells, (ii) their directed differentiation into regenerative populations, (iii) the non-destructive dissociation of differentiated cellular aggregates into single cell suspensions, (iv) purification techniques for positive selection and (v) point-of-care processing which includes cryopreservation, shipping, thawing, washing and presentation of the final therapy ready for administration. The overall goal of this program of work is to develop platform technologies for the manufacture of stem cell therapies.
Teaching and Training Activities
Farlan Veraitch teaches a number of fundamental Biochemical Engineering courses including Mass and Energy Balances for first year undergraduate students and Heat Transfer for second year undergraduates. Farlan is the first year undergraduate tutor and is responsible for mammalian cell culture teaching in the department. In terms of post-graduate activities he co-ordinates the Mammalian Cell Culture MBI module, the MSC design project and teaches on the Regenerative Medicine MBI module.
Selected Publications
*If you would like further information on any of these publications or news of related research, please contact f.veraitch@ucl.ac.uk
Mondragon-Teran, P., Tostoes, R., Mason, C., Lye, G.J., Veraitch, F.S. (2013) Oxygen-controlled automated neural differentiation of mouse embryonic stem cells. Regen Med. 8(2):171-82.
Reichen M., Macown, R.J., Jaccard, N., Super, A., Ruban, L., Griffin, L.D., Veraitch, F.S., Szita, N. (2012) Microfabricated modular scale-down device for regenerative medicine process development. PLoS One 7(12):e52246
Bae, D., Mondragon-Teran, P., Hernandez, D., Ruban, L., Mason, C., Bhattacharya, S.S., Veraitch, F.S. (2012) Hypoxia enhances the generation of retinal progenitor cells from human induced pluripotent and embryonic stem cells. Stem Cells Development 21(8):1344-1355
Badger, J.L., Byrne, M.L., Veraitch, F.S., Mason, C., Caldwell, M.A., Wall, I.B. (2012) Hypoxic culture of human pluripotent stem cell lines is permissible using mouse embryonic fibroblasts. Regenerative Medicine 7(5):675-683
Mondragon-Teran, P., Baboo, J.Z., Mason, C., Lye, G.J., Veraitch, F.S. (2011) The full spectrum of physiological oxygen tensions and step-changes in oxygen tension affects the neural differentiation of mouse embryonic stem cells. Biotechnology Progress 27(6):1700-1708
Papantoniou, I., Hoare, M., Veraitch, F.S. (2011) The release of single cells from embryoid bodies in a capillary flow device. Chemical Engineering Science 66, 570-581
Hemsley, A. L., Hernandez, D., Mason, C., Pelling, A. E., Veraitch, F. S. (2011). Precisely delivered nano-mechanical forces induce blebbing in undifferentiated mouse embryonic stem cells. Cell Health and Cytoskeleton 3, 23 - 34
Veraitch, F. S., Lye, G. J. (2010). Automated stem cell culture with a twist. Genetic Engineering News 30(8), 40-42
Lye, G. J., Veraitch, F. S. (2009). Consistency and reproducibility in stem cell culture. Tecan Journal 3(12), 13-14
Mondragon-Teran, P., Lye, G. J., Veraitch, F. S. (2009). Lowering oxygen tension enhances the differentiation of mouse embryonic stem cells into neuronal cells. Biotechnology Progress 25(5), 1480-1488
Pelling, A. E., Veraitch, F. S., Chu, C. P., Mason, C., Horton, M. A. (2009). Mechanical dynamics of single cells during early apoptosis. Cell Motility and the Cytoskeleton 66(7), 409-22
Veraitch, F. S., Scott, R., Wong, J. W., Lye, G. J., Mason, C. (2008). The impact of manual processing on the expansion and directed differentiation of embryonic stem cells. Biotechnology and Bioengineering 99(5), 1216-1229
Pelling, A. E., Veraitch, F. S., Chu, C., Nicholls, B. M., Hemsley, A. L., Mason, C., Horton, M. A. (2007). Mapping of correlated cell membrane pulsations and fluctuations in human cells. Journal of Molecular Recognition 20(6), 467-476
Veraitch, F. S., Al-Rubeai, M. (2005). Enhanced growth in NS0 cells expressing aminoglycoside phosphotransferase is associated with changes in metabolism, productivity and apoptosis. Biotechnology and Bioengineering 92(5), 589-599
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