Nigel Titchener-Hooker
Professor of Biochemical Engineering
Head of Department
Director of The Advanced Centre for Biochemical Engineering
Director of the Innovative Manufacturing Research Centre for Bioprocessing
Phone: +44 (0)20 7679 7031
Fax: +44 (0)20 7383 2378
nigelth@ucl.ac.uk
Education
PhD Biochemical Engineering, University College London (1987)
BSc (Hons) Chemical Engineering, UMIST (1983)
Professional Appointments, Honours and Awards
Fellow of the Royal Academy of Engineering
Fellow of the Institution of Chemical Engineering
Council Member of the Institution of Chemical Engineering (1995-1997)
Editorial Board for Bioprocess and Biosystems Engineering
Editorial Board for Biotechnology and Bioengineering
Subject Editor for Trans. IChemE (Part C)
Member, Engineering Council Nominations and Audit Committee (1996 - 2002)
Member, American Institute of Chemical Engineers
Member, EPSRC Peer Review College
Conference Chair, Recovery of Biological Products XI & XIV
Board Member of Recovery of Biological Products – Conference Series
Member, Organizing Committee 2000 World Congress of Chemical Engineering
Member, IChemE Membership Committee
Member, BioProcess UK Advisory Board
Member, BRIC Steering Group
Member, IBC Scientific Advisory BoardEsso Centenary Fellowship (1990-1994)
Esso Centenary Fellowship (1990-1994)
Research Interests
Nigel Titchener-Hooker leads the UCL Innovative Manufacturing Research Centre (IMRC) in Bioprocessing programme. This involves a multidisciplinary group from over a dozen departments to research new methods to speed the development of efficient and robust processes for the manufacture of the next generations of macromolecular drugs. The work brings together researchers from Structural and Molecular Biology (Professor John Ward), and within the Faculty of Engineering Science significant collaborations exist with Computer Science (Professor Tony Hunter), Chemical Engineering (Dr. Eva Sorenson and Dr. Lazaros Papageorgiou). Internally Dr. Dan Bracewell, Dr. Nicolas Szita, Dr. Yuhong Zhou, Dr. Eli Keshavarz-Moore and Professor Mike Hoare help Nigel in the management of the IMRC consortium that comprises 15 leading national and international companies.
A major focus of Nigel’s work is the creation of whole bioprocess models and the use of these to gain process insights and understanding. Here he works with Dr. Yuhong Zhou in the creation of graphical user interfaces to visualise better process trade offs. With Dr. Suzanne Farid, Nigel has pioneered studies of decisional tools addressing the interface between bioprocessing and business issues.
In line with the theme of whole bioprocess modelling, Nigel has collaborated with colleagues at Newcastle University (Professor Gary Montague, Professor Elaine Martin and Dr. Jarka Glassey) to create new ways of improving the performance of manufacturing processes by combining IMRC tools with agent-based methods.
Nigel chairs the Engineering Doctorate (EngD) in Bioprocess Leadership activity now directed by Prof Gary Lye. Since its inception the EngD programme has attracted over 50 sponsor companies to date and nearly 100 projects have been funded under this mechanism which complements the research within the Department.
Funding for the above research has come from the UK EPSRC, the TSB Technology Programme and a range of company collaborators.
Teaching and Training Activities
Nigel’s current teaching portfolio extends across all of the department’s programmes and include a major emphasis on Integrated Downstream Processing, Fluid Flow Fundamentals and Materials of Construction. He teaches on aspects of primary recovery and chromatographic purification.
Selected Publications
*If you would like further information on any of these publications or news of related research, please contact nigelth@ucl.ac.uk
Joseph, J.R . , Tran, R.Y., Bracewell, D., Zhou, Y., Titchener-Hooker , N.J. 2007. A framework for the prediction of scale-up when using compressible chromatographic packings. Biotech. Progress. 23(2): 413-422. doi:10.1021/bp060303i
Pampel, L., Boushaba, R., Udell, M., Turner, M.K., Titchener-Hooker, N.J. 2007. The influence of major components on the direct chromatographic recovery of a protein from transgenic milk. J Chrom. A. 1142, 137-147. doi:10.1016/j.chroma.2006.12.043
Siu, S.C., Topoyassakul, V., Graham, A., Choudhary, S., Moss, G., Titchener-Hooker, N.J. 2006. Visualising fouling of a chromatographic matrix using confocal scanning laser microscopy. Biotech Bioeng. 95(4): 714-723. doi:10.1002/bit.21028
Salisbury, R., Bracewell, D.G., Titchener-Hooker, N.J. 2006. A methodology for the graphical determination of operating conditions of chromatographic sequences incorporating the trade-offs between purity and yield. J. Chem . Tech . Biotech. 81, 1803-1813. doi:10.1002/jctb.1607
Salte, H., King, J.M.P., Baganz, F., Hoare, M., Titchener-Hooker, N.J. 2006. A methodology for centrifuge selection for the separation of high solids density cell broths by visualisation of performance using windows of operation. Biotech. Bioeng. 95(6): 1218-1227. doi:10.1002/bit.21102
Farid, S.S., Washbrook, J., Titchener-Hooker, N.J. 2005. Decision-Support Tool for Assessing Bio-Manufacturing Strategies under Uncertainty: Stainless steel versus Disposable Equipment for Clinical Trial Material Preparation. Biotechnol. Prog. 21(2): 486-497 doi:10.1021/bp049692b
Nealon, A. Lye, G.J., O’Kennedy, R., Titchener-Hooker, N.J. 2005. “Use of operating windows in the assessment of integrated robotic systems for the measurement of bioprocess kinetics.” Biotechnol. Progress. 21, 283-291. doi:10.1021/bp049868+
Rajapakse, A., Titchener-Hooker, N. J., Farid, S. 2005. Modelling of the biopharmaceutical drug development pathway and portfolio management. Comput. Chem. Eng. 29(6): 1357-1368. doi:10.1016/j.compchemeng.2005.02.010
Gardner, P.A., Willoughby, N.A., Lacki, K., Hjorth, R., Titchener-Hooker, N.J. 2004. An investigation of the performance of expanded beds formed from classified particle distributions – implication for scale-up. Biotech. Bioeng. 87(3): 347-353. doi:10.1002/bit.20119
Meacle, F.J., Lander, R., Ayazi Shamlou, P., Titchener-Hooker, N.J. 2004. Impact of engineering flow conditions on plasmid DNA yield and purity in chemical cell lysis operations. Biotech. Bioeng. 87(3): 293-302. doi:10.1002/bit.20114
Pate, M.E., Thornhill, N.F., Turner, M.K., Titchener-Hooker, N.J. 2004. Principal Component Analysis of Nonlinear Chromatography. Biotechnol. Prog. 20(1): 215 -222. doi:10.1021/bp034133a
Willoughby, N.A., Martin, P.L., Titchener-Hooker, N.J. 2004. Extreme scale-down of Expanded bed Adsorption: Purification of an Antibody Fragment directly from Recombinant E.coli culture. Biotech. Bioeng. 87(5): 641-647. doi:10.1002/bit.20173
Zhou, Y. and Titchener-Hooker, N.J. 2003. The application of a Pareto optimisation method in the design of an integrated bioprocess. Bioprocess and Biosystems Engineering. 25(6): 349-355. doi:10.1007/s00449-003-0318-0
Byrne, E.P., Fitzpatrick, J.J., Pampel, L.W., Titchener-Hooker, N.J. 2002. Influence of shear on particle size and fractal dimension of whey protein precipitates: Implications for scale-up and centrifugal clarification efficiency. Chem. Eng. Sci. 57(18): 3767-3779.
doi:10.1016/S0009-2509(02)00315-9
Ciccolini, L.A.S., Ayazi Shamlou, P., Dunnill, P., Titchener-Hooker, N.J. 2002. A mass balance study of the effects of the primary recovery of plasmid DNA from Escherichia coli.Biotech. Bioeng. 77(7): 796-805. doi:10.1002/bit.10166
Return to view the full staff list...
Page last modified on 20 sep 11 12:27
