Tarit Mukhopadhyay
Lecturer in Vaccine Bioprocess Development
Schools Outreach: Talks and Visits
Phone: + 44 (0)20 7679 0438
Fax: + 44 (0)20 7916 3943
t.mukhopadhyay@ucl.ac.uk
Education
EngD (Engineering Doctorate) in Biochemical Engineering, University College London, (2008).
M.Eng in Biochemical Engineering with Study Abroad, University College London and University of Massachusetts, (2002)
Professional Appointments, Honours and Awards
Treasurer, Process Engineering Group, Society of Chemical Industry, (2003-2005)
Messel Bursary Award (2004)
Associate Member of the Institute of Chemical Engineers, (2002)
Sir Derek Roberts Scholarship in Biochemical Engineering, (1999)
Research Interests
Tarit’s research area is in vaccine bioprocess development. Vaccination is the most significant and successful public health policy of the 20th century. It is through vaccination that over 2 million lives a year are saved, increasing life expectancy by 30 years, adding over $1 billion to the global economy. However, the translation of new ideas from discovery to commercialisation can present unique process challenges – particularly in maintaining the potency and quality of the vaccine antigen.
As part of his doctoral studies in a joint project with the Health Protection Agency and Prof Gary Lye in the IMRC in Bioprocessing, Tarit focused on the development of a microwell platform for rapid vaccine development. This platform was applied to the development of a new Meningitis B vaccine now in clinical trials. The platforms usefulness and robustness was also tested with the UK Anthrax Vaccine, ( AVP) – utilised to gather deeper process insight under ACDP Class 3 conditions.
His current research focus is on aggregation phenomena and its impact on downstream processing, particularly with virus like particle vaccines; a collaborative project with Intercell AG and Prof Nigel Titchener-Hooker on the next generation Japanese Encephalitis virus vaccine and bioprocessing of RNA/ DNA vaccines with Dr Eli Keshevarz-Moore and Prof John Ward.
Teaching and Training Activities
Tarit is responsible for co-ordination of all vaccine related teaching activities across the Department. The possibilities of an AIDS vaccine have been met with increased scientific and media interest and Tarit challenges his 1 st year undergraduates to consider the possibilities of an AIDS vaccine, its delivery, distribution and financing.
He also delivers a series of lectures to MEng and Msc students regarding the latest advanced in vaccine technology as well as the ethics and economics of vaccine development.
Publications
*If you would like further information on any of these publications or news of related research, please contact t.mukhopadhyay@ucl.ac.uk
Mukhopadhyay, T.K. 2006. Clinical trials in Developing Nations. Chemistry & Industry, 22, 16
Mukhopadhyay, T.K. 2006. Chemistry must inspire. Chemistry & Industry, 8, 18
Mukhopadhyay, T.K., Gorringe, A, Charlton, S., Allison, N., Levy, M.S., Ward, J., Lye, G.J. 2006. Rapid Vaccine Development using Microwell based Platforms. ECI Vaccine Technology, poster presentation, Puerto Vallarta, Mexico, 25-30 June.
Mukhopadhyay, T.K., Halliwell, D., O’Dwyer, C., Shamlou, P.A., Levy, M.S., Allison, N., Gorringe, A., Reddin, K.M. 2005. Rapid characterization of outer membrane proteins in N.lactamica by SELDI- TOF mass spectroscopy for use in a meningococcal vaccine. Biotechnology and Applied Biochemistry, 41, 175-82 DOI 10.1042/BA20040098
Mukhopadhyay, T.K., Reddin, K.M., Gorringe, A., Allison, N., Lye, G.J., Levy, M.S. 2004. The use of Microwell Technology for rapid process development of a meningococcal vaccine based on outer membrane proteins from N.lactamica. 12 th International Symposium on Biotechnology, poster presentation, Santiago, Chile, 17-22 October.
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