Eli Keshavarz-Moore
Professor of Biochemical Engineering
Tutor MEng Biochemical Engineering with Bioprocess Management
UG Exams Co-ordinator
Year 3 Tutor (including EMY)
Graduate Careers Co-ordinator
Phone: +44 (0)20 7679 2961
Fax: +44 (0)20 7209 0703
e.keshavarz-moore@ucl.ac.uk
Education
PhD Biochemical Engineering, University of London (1988)
MSc Chemical Engineering, University of Melbourne, Australia (1985)
MSc Management Science, University of London (1977)
BSc Chemical Engineering, University of London (1976)
Professional Appointments, Honours and Awards
Reader, Department of Biochemical Engineering, UCL (2006-present)
Senior Lecturer, Department of Biochemical Engineering, UCL (1998-2006)
Lecturer, Biochemical Engineering, UCL (1990-1998)
Honorary Lecturer, Department of Chemical and Biochemical Engineering,UCL (1988-1990)
Consultant, Coopers & Lybrand Associates Limited, U.K. (1979-1983)
Analyst, ICL Dataskil , U.K. (1978-1979)
Corporate Member, Institution of Chemical Engineers
Member, judging panel. SET for Britain and Europe award (2005-present)
Research Interests
Eli Keshavarz-Moore’s research interest is in the bioprocessing of complex macromolecules with therapeutic promise including fusion proteins, antibody fragments (monoclonal and polyclonal), artificial chromosomes and phages; and cells including microbial, mammalian and fungal systems as well as transgenic materials. One particular aspect is how to control and manipulate the upstream processing including fermentation and cell engineering in order to facilitate the whole processing sequence with the ultimate aim of creating a step change in design and operation of the entire processes. As one of the Principal Investigators in the Innovative Manufacturing Research Centre (IMRC) in Bioprocessing she is working with other members of staff in the Department (particularly Prof. Nigel Titchener-Hooker and Dr Frank Baganz) and with Prof. John Ward (Biochemistry and Molecular Biology) with whom she also has further grant collaborations. Her transgenic research is currently aimed at using micro biochemical engineering to address the design of transgenic products in plants. This has been in collaboration with St Georges Hospital and Birmingham University.
Teaching and Training Activities
Since 2000, Eli Keshavarz-Moore has led the development and implementation of innovative enterprise training at the bioprocessing/life sciences interface. The training program encompasses a range of courses at undergraduate and postgraduate levels and has extended to include business enterprise for industry in the healthcare and biotechnology sectors. As a result, over 600 students have been trained from across UCL, including the Faculties of Engineering Sciences, Life Sciences and Medicine together with a mix of post-experience delegates from other institutions including the London Business School.
Selected Publications
*If you would like further information on any of these publications or news of related research, please contact
e.keshavarz-moore@ucl.ac.uk
Chhatre, S., Francis, R., O’Donovan, K., Titchener-Hooker , N.J. , Newcombe, A.R., Keshavarz-Moore, E. 2007. A decision-support model for evaluating changes in biopharmaceutical manufacturing processes. Bioprocess and Biosystems Engineering. 30 (1): 1-11.
doi: 10.1007/s00449-006-0086-8
Thillaivinayagalingam, P., O’Donovan, K., Newcombe, A.R., Keshavarz-Moore, E. 2007. Characterisation of an industrial affinity process used in the manufacturing of digoxin-specific polyclonal Fab fragments, Journal of Chromatography B. 848 (1): 88-96 doi:10.1016/j.jchromb.2006.03.065
Chhatre, S., Thillaivinayagalingam, P., Francis, R., Titchener-Hooker, N.J., Newcombe A.R. and Keshavarz-Moore, E. 2007. Decision-Support Software for the Industrial-Scale Chromatographic Purification of Antibodies, Biotechnology Progress. 23, 4, 888-894,
doi:10.1021/bp070062u
Lewis, W., Keshavarz-Moore, E., Windust, J., Bushell, D., Parry, N. 2006. C onstruction and evaluation of novel fusion proteins for targeted delivery of micro particles to cellulose surfaces, Biotechnology and Bioengineering. 94, 625-632. doi:10.1002/bit.20849
Chhatre, S., Jones, C., Francis, R., O’Donovan, K., Titchener-Hooker , N.J. , Newcombe, A.R., Keshavarz-Moore, E. 2006. The integrated simulation and assessment of the impacts of process change in biotherapeutic antibody production, Biotechnology progress. 22, 1612-1620. doi: 10.1021/bp0602000
Cooke,J.R., McKie,E.A., Ward,J.M., Keshavarz-Moore. E . 2004. Impact of intrinsic DNA structure on processing of plasmids for gene therapy and DNA vaccines.Journal of Biotechnology. 114(3): 239-254. doi:10.1016/j.jbiotec.2004.06.011
Kay, A., O’Kennedy, R.D., Ward, J.M., Keshavarz-Moore, E. 2003. Impact of plasmid size on cellular oxygen demand in Escherichia coli. Biotech. Appl. Biochem. 38, 1-7. doi:bab/038/0001/0380001
Neal, G., Christie, J., Shamlou, P.A., Keshavarz-Moore, E. 2003. An ultra scale-down approach for the prediction of full-scale recovery of ovine polyclonal immunoglobulins used in the manufacture of snake venom-specific Fab fragment. Biotech. Bioeng. 81, 149-157
doi:10.1002/bit.10454
O’Kennedy, R.D., Ward, J.M., Keshavarz-Moore, E. 2003. Effects of fermentation strategy on the characteristics of plasmid DNA production. Biotechnol. Appl. Biochem. 37, 83-90. doi: bab/037/0083/0370083
Boulding, N., Yim, S.S.S., Keshavarz-Moore, E., Ayazi-Shamlou, P., Berry, M. 2002. Ultra scale-down to predict filtering centrifugation of secreted antibody fragments from fungal broth. Biotech. Bioeng. 78 (4): 381-388. doi: 10.1002/bit.10306
Nichols, K., Stanislaus, D., Keshavarz-Moore, E. 2002. Young disruption of leaves and initial extraction of wild type cowpea mosaic virus as a basis for producing vaccines from plants. J. Biotech. 92 (3): 229-235. doi:10.1016/S0168-1656(01)00348-0
Pierce, J.J., Robinson , S.C. , Ward, J.M., Keshavarz-Moore, E., Dunnill, P. 2002. A comparison of the process issues in expressing the same recombinant enzyme periplasmically in E. coli and extracellularly in S. lividans. J. Biotech. 92 (3): 205-215.
doi:10.1016/S0168-1656(01)00322-4
Sotiriadis, A., Keshavarz, T., Keshavarz-Moore, E. 2001. Factors affecting the production of a single-chain antibody fragment in Aspergillus awamori in a stirred tank reactor. Biotech. Prog. 17 (4): 618-623. doi:10.1021/bp010026+
O’Kennedy, R.D., Baldwin , C., Keshavarz-Moore, E. 2000. Effects of growth medium selection on plasmid DNA production and initial processing steps. J. Biotech. 76, 175-183. doi:10.1016/S0168-1656(99)00187-X
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