UCL/UCLH Biobank for Studying Health and Disease(based at Pathology-Rockefeller Building and UCL-Cancer Institute)

This biobank has been primarily established to support the Research Programme and scientific needs, of the Pathology Department UCLH & the UCL Cancer Institute. The establishment of the core programme enables a centralised approach to the management and integration of all research groups working within these institutions, providing appropriate structure and support. The biobank has policies and guidelines to guarantee compliance with HTA legislation and to ensure quality standards will be maintained.

The biobank stores normal and pathological specimens, surplus to diagnostic requirements, from relevant tissues and bodily fluids, as well as human tissue used in xenograft experiments. Stored tissues include; snap-frozen or cryopreserved tissue, formalin-fixed tissue, paraffin-embedded tissues, and slides prepared for histological examination. Tissues include resection specimens obtained surgically or by needle core biopsy. Bodily fluids include; whole blood, serum, plasma, urine, cerebrospinal fluid, milk, saliva and buccal smears and cytological specimens such as sputum and cervical smears. Fine needle aspirates obtained from tissues and bodily cavities (eg. pleura and peritoneum) are also collected. Where appropriate the biobank also stores separated cells, protein, DNA and RNA isolated from collected tissues and bodily fluids described above. Some of the tissue and aspirated samples are stored in the diagnostic archive.

The biobank is governed by the Biobank Ethical Review Committee (B-ERC), which represents a range of stakeholders working together to maximise the potential of the samples stored or registered with the biobank. The Committee ensure that there is good governance, appropriate links to the relevant communities, and that progress, output and the development of the biobank is regularly monitored. It considers the concerns of sample donors and the tissue depositors and makes recommendations to ensure direct benefit of the biobank to ongoing medical research. The Committee reviews requests for new sample collections and also requests for use of samples/data for research, including those which do not already have ethical approval and ensure they satisfy conditions laid down by NRES for the release of tissues by the Research Tissue Bank. B-ERC reports to the Clinical Research Governance Committee  and the UCL Human Tissue Authority Licence DI/PD group. 

Page last modified on 30 jul 14 15:54