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UCL Knowledge Transfer

UCL Enterprise has appointed seven Knowledge Transfer Champions from UCL's academic staff to support and celebrate some of the knowledge transfer projects going on at one of the world's top universities. The seven academics include Barry Fuller and Brian Davidson who will be developing an information pack and delivering a series of workshops, web-based interactive studies and a documentary manual around Human Organs, Cells and Tissues for research and therapy.

UCL Knowledge Transfer. Human Organs, Cells and Tissues: Research; Therapy; the Future

Professors Barry Fuller & Brian Davidson, Division of Surgery & Interventional Science, Royal Free Campus, UCL. Contacts : b.fuller@medsch.ucl.ac.uk b.davidson@ucl.ac.uk

Background and current activities

Whilst use of human organs, cells and tissues (h-oct) has permitted great advances in therapy, fundamental and translational research over the past 40 years, it can be quite challenging for groups from different parts of the access delivery and biopreservation pathway, to understand each other's requirements and access parts of the process map relevant to their needs. Professors Barry Fuller (BJF) and Brian Davidson (BRD) have many years experience within clinical organ transplantation, the national organ retrieval service, other surgical procedures, interfaces with biotechnology, UCL contracts, and regulators such as the Human Tissue Authority.  This work is complemented by the development of infrastructures for biobanking and platform technologies. Hence, this knowledge transfer initiative is aimed at delivering this comprehensive overview to the UCL community via profile-raising events, a web site with quality manual and process maps, and DVD-based tutorials.

Work Area including Links to Industry, Service Provision, Current Funding.

Access to and exploitation of h-oct inevitably require interface with patients for living donation and ranking associates of the donor for donation after death, wherein the fundamental principle of consent is paramount. The process pathway (below) moving from the right shows access to h-oct as currently ongoing across UCL P. The Knowledge Transfer delivery will revolve around the three complimentary and overlapping Focus Groups.

KT pic

The interactions and players in the three Focus Groups are shown in the diagram. The 1st focus group (purple pathway) shows Access to h-oct donated for approved research either via UCL P clinical services (D1a) or NHSBT National Organ Retrieval Service (NORS – D1b). Thereafter H-oct passes to end users for in-house UCL research or to approved biotechnology via contracts and translational research organised via UCL B and UCL Contracts (reg D2), which ensure probity. External regulatory agencies (regD1) provide regulatory oversight (dashed) areas on the overall process. End user research (D3, D4) proceeds in UCL or outside agencies, with the potential for academic collaboration on specific projects. By bringing these together, cross-disciplinary collaboration will be facilitated. The second grouping (green pathway) shows a focus meeting where NHSBT Organ Donor Transplant (T1) and UCL P services (T2) involved in both clinical and research aspects can be brought together to impart knowledge on their activities and flag up potential areas for research and translation. Here, it will be possible to show-case debates on the separate issues surrounding philosophy and ethics (rT1)of h-oct use now and for the next decade. The 3rd focus grouping (blue pathway) will bring together the biotechnology companies involved in developing next generation technologies for cell therapies, and implantable materials or cell isolation technologies to support such cell-based implants (R1) which may be the future of transplantation, with UCL regenerative medicine groups at the forefront of research in this area (R2). In addition the supporting commercial technologies for cryo-banking and cold chain delivery will be represented (R3).

For each focus group a 1 day event will be organised, with relevant invited speakers and commercial / agency displays appropriate to the topic. Speakers will be required to contribute to the dvd-based compendium to be recorded at the event, and a text for the KT manual. The relevant information will compiled into both brochure-style material for easy first access for the UCL community, supplemented by an in-depth Quality Manual describing the overall area of interest which will be made available on the web for UCL and UCL P users.

Work Plan :

A postdoctoral fellow will be recruited (80%) for this project shortly to develop the initiative as follows:

Set-up: Focus 1, web page, manual T= 0-4 months

Run Focus 1, set-up Focus 2, manual T= 4-7 months

Run Focus 2, set up Focus 3 T= 7-10 months

Complete manual, SOPs, web page T= 10-12 Months

Contact Info:

The Postdoctoral Fellow, Amir Gander, is now in place for this initiative and can be contacted at a.gander@medsch.ucl.ac.uk

Amir has now set up a website for this initiative - Tissue Access for Patient Benefit (TAPb), with further details and information on regulation and ethics for use of human samples https://www.ucl.ac.uk/tapb/homepage

Page last modified on 31 oct 11 16:08 by Kirstin Goldring