Centre for Amyloidosis and Acute Phase Proteins
Centre for Amyloidosis and Acute Phase Proteins

Medicine News

Major Grants from 1st August 2013

Published: Jul 31, 2014 12:23:05 PM

UCL Stroke Case Collection (UStroc)

Published: Jun 30, 2014 4:17:48 PM

Rajiv Jalan

Published: Jun 30, 2014 11:28:01 AM

Key Publications

  1. Mangione, P.P., Esposito, G., Relini, A., Raimondi, S., Porcari, R., Giorgetti, S., Corazza, A., Fogolari, F., Penco, A., Goto, Y., Lee, Y.H., Yagi, H., Cecconi, C., Naqvi, M.M., Gillmore, J.D., Hawkins, P.N., Chiti, F., Rolandi, R., Taylor, G.W., Pepys, M.B., Stoppini, M. and Bellotti, V. (2013) Structure, folding dynamics and amyloidogenesis of Asp76Asn beta-2‑microglobulin: roles of shear flow, hydrophobic surfaces and alpha crystallin. J. Biol. Chem. [Epub ahead of print].
  2. Simons, J.P., Al‑Shawi, R., Ellmerich, S., Speck, I., Aslam, S., Hutchinson, W.L., Mangione, P.P., Disterer, P., Gilbertson, J.A., Hunt, T., Millar, D.J., Minogue, S., Bodin, K., Pepys, M.B. and Hawkins, P.N. (2013) Pathogenetic mechanisms of amyloid A amyloidosis. Proc. Natl. Acad. Sci. USA, 110: 16115-16120.
  3. Valleix, S., Gillmore, J.D., Bridoux, F., Mangione, P.P., Dogan, A., Nedelec, B., Boimard, M., Touchard, G., Goujon, J.‑M., Lacombe, C., Lozeron, P., Adams, D., Lacroix, C., Maisonobe, T., Planté‑Bordeneuve, V., Vrana, J.A., Theis, J.D., Giorgetti, S., Porcari, R., Ricagno, S., Bolognesi, M., Stoppini, M., Delpech, M., Pepys, M.B., Hawkins, P.N. and Bellotti, V. (2012) Hereditary systemic amyloidosis due to Asp76Asn variant beta-2‑microglobulin. N. Engl. J. Med., 366: 2276‑2283.
  4. Emerging Risk Factors Collaboration, Kaptoge, S., et al., Pepys, M.B., Thompson, S.G. and Danesh, J. (2012) C‑reactive protein, fibrinogen, and cardiovascular disease prediction. N. Engl. J. Med., 367: 1310‑1320.
  5. C Reactive Protein Coronary Heart Disease Genetics Collaboration (CCGC), Wensley, F., Gao, P., Burgess, S., Kaptoge, S., Di Angelantonio, E., Shah, T., Engert, J.C., Clarke, R., Davey-Smith, G., Nordestgaard, B.G., Saleheen, D., Samani, N.J., Sandhu, M., Anand, S., Pepys, M.B., Smeeth, L., Whittaker, J., Casas, J.P., Thompson, S.G., Hingorani, A.D. and Danesh, J. (2011) Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data. B.M.J., 342: d548.
  6. Kolstoe, S.E., Mangione, P.P., Bellotti, V., Taylor, G.W., Tennent, G.A., Deroo, S., Morrison, A.J., Cobb, A.J.A., Coyne, A., McCammon, M.G., Warner, T.D., Mitchell, J., Gill, R., Smith, M.D., Ley, S.V., Robinson, C.V., Wood, S.P. and Pepys, M.B. (2010) Trapping of palindromic ligands within native transthyretin prevents amyloid formation. Proc. Natl. Acad. Sci. USA, 107: 20483-20488.
  7. Bodin, K., Ellmerich, S., Kahan, M.C., Tennent, G.A., Loesch, A., Gilbertson, J.A., Hutchinson, W.L., Mangione, P.P., Gallimore, J.R., Millar, D.J., Minogue, S., Dhillon, A.P., Taylor, G.W., Bradwell, A.R., Petrie, A., Gillmore, J.D., Bellotti, V., Botto, M., Hawkins, P.N. and Pepys, M.B. (2010) Antibodies to human serum amyloid P component eliminate visceral amyloid deposits. Nature, 468: 760-767.
  8. Gillmore, J.D., Tennent, G.A., Hutchinson, W.L., Gallimore, J.R., Lachmann, H.J., Goodman, H.J.B., Offer, M., Millar, D.J., Petrie, A., Hawkins, P.N. and Pepys, M.B. (2010) Sustained pharmacological depletion of serum amyloid P component in patients with systemic amyloidosis. Br. J. Haematol., 148: 760-767.
  9. Emerging Risk Factors Collaboration, Kaptoge, S., Di Angelantonio, E., Lowe, G., Pepys, M.B., Thompson, S.G., Collins, R., Danesh, J., et al. (2010) C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis. Lancet, 375: 132-140.
  10. Kolstoe, S.E., Ridha, B.H., Bellotti, V., Wang, N., Robinson, C.V., Crutch, S.J., Keir, G., Kukkastenvehmas, R., Gallimore, J.R., Hutchinson, W.L., Hawkins, P.N., Wood, S.P., Rossor, M.N. and Pepys, M.B. (2009) Molecular dissection of Alzheimer's disease neuropathy by depletion of serum amyloid P component. Proc. Natl. Acad. Sci. USA, 106: 7619-7623.
  11. Lachmann, H.J., Kone-Paut, I., Kuemmerle-Deschner, J.B., Leslie, K.S., Hachulla, E., Quartier, P., Gitton, X., Widmer, A., Patel, N. and Hawkins, P.N.; Canakinumab in CAPS Study Group (2009) Use of canakinumab in the cryopyrin-associated periodic syndrome. N. Engl. J. Med., 360: 2416-2425.
  12. Lachmann, H.J., Goodman, H.J.B., Gilbertson, J.A., Gallimore, J.R., Sabin, C.A., Gillmore, J.D. and Hawkins, P.N. (2007) Natural history and outcome in systemic AA amyloidosis. N. Engl. J. Med., 356: 2361-2371.
  13. Dember, L.M., Hawkins, P.N., Hazenberg, B.P., Gorevic, P.D., Merlini, G., Butrimiene, I., Livneh, A., Lesnyak, O., Puechal, X., Lachmann, H.J., Obici, L., Balshaw, R., Garceau, D., Hauck, W. and Skinner, M. (2007) Eprodisate for the treatment of renal disease in AA amyloidosis. N. Engl. J. Med., 356: 2349-2360.
  14. Pepys, M.B., Hirschfield, G.M., Tennent, G.A., Gallimore, J.R., Kahan, M.C., Bellotti, V., Hawkins, P.N., Myers, R.M., Smith, M.D., Polara, A., Cobb, A.J.A., Ley, S.V., Aquilina, J.A., Robinson, C.V., Sharif, I., Gray, G.A., Sabin, C.A., Jenvey, M.C., Kolstoe, S.E., Thompson, D. and Wood, S.P. (2006) Targeting C-reactive protein for treatment of cardiovascular disease. Nature, 440: 1217-1221.
  15. Pepys, M.B. (2006) Amyloidosis. Annu. Rev. Med., 57: 223-241.
  16. Stangou, A.J., Heaton, N.D. and Hawkins, P.N. (2005) Transmission of systemic transthyretin amyloidosis by means of domino liver transplantation. N. Engl. J. Med., 352: 2356.
  17. Pepys, M.B. (2005) CRP or not CRP? That is the question. Arterioscler. Thromb. Vasc. Biol., 25: 1091-1094.
  18. Danesh, J., Wheeler, J.G., Hirschfield, G.M., Eda, S., Eiriksdottir, G., Rumley, A., Lowe, G.D.O., Pepys, M.B. and Gudnason, V. (2004) C-reactive protein and other circulating markers of inflammation in the prediction of coronary heart disease. N. Engl. J. Med., 350: 1387-1397.
  19. Pepys, M.B. and Hirschfield, G.M. (2003) C-reactive protein: a critical update. J. Clin. Invest., 111: 1805-1812.
  20. Hawkins, P.N., Lachmann, H.J. and McDermott, M.F. (2003) Interleukin-1-receptor antagonist in the Muckle-Wells syndrome. N. Engl. J. Med., 348: 2583-2584.
  21. Lachmann, H.J., Booth, D.R., Booth, S.E., Bybee, A., Gilbertson, J.A., Gillmore, J.D., Pepys, M.B. and Hawkins, P.N. (2002) Misdiagnosis of hereditary amyloidosis as AL (primary) amyloidosis. N. Engl. J. Med., 346: 1786-1791.
  22. Pepys, M.B., Herbert, J., Hutchinson, W.L., Tennent, G.A., Lachmann, H.J., Gallimore, J.R., Lovat, L.B., Bartfai, T., Alanine, A., Hertel, C., Hoffmann, T., Jakob-Roetne, R., Norcross, R.D., Kemp, J.A., Yamamura, K., Suzuki, M., Taylor, G.W., Murray, S., Thompson, D., Purvis, A., Kolstoe, S., Wood, S.P. and Hawkins, P.N. (2002) Targeted pharmacological depletion of serum amyloid P component for treatment of human amyloidosis. Nature, 417: 254-259.

Laboratory for Protein Crystallography

  1. Pal, M., Erskine, P.T., Gill, R.S., Wood, S.P. and Cooper, J.B. (2010) Near-atomic resolution analysis of BipD, a component of the type III secretion system of Burkholderia pseudomallei. Acta Cryst., F66: 990-993.
  2. Kolstoe, S.E. and Wood, S.P. (2010) Drug targets for amyloidosis. Biochem. Soc. Trans., 38: 466-470.
  3. Montgomery, M.G., Coker, A.R., Taylor, I.A. and Wood, S.P. (2010) Assembly of a 20-nm protein cage by Escherichia coli 2-hydroxypentadienoic acid hydratase. J. Mol. Biol., 396: 1379-1391.
  4. Bowyer, A., Mikolajek, H., Stuart, J.W., Wood, S.P., Jamil, F., Rashid, N., Akhtar, M. and Cooper, J.B. (2009) Structure and function of the L-threonine dehydrogenase (TkTDH) from the hyperthermphilic archaeon Thermococcus kodakaraensis. J. Struct. Biol., 168: 294-304.
  5. Gill, R., Kolstoe, S.E., Mohammed, F., Al D-Bass, A., Mosely, J.E. Sarwar, M., Cooper, J.B., Wood, S.P. and Shoolingin-Jordan, P.M. (2009) Structure of human porphobilinogen deaminase at 2.8 Å: the molecular basis of acute intermittent porphyria. Biochem. J., 420: 17-25.
  6. Erskine, P.T., Knight, M.J., Ruaux, A., Mikolajek, H., Wong Fat Sang, N., Withers, J., Gill, R., Wood, S.P., Wood, M., Fox, G.C. and Cooper, J.B. (2006) High resolution structure of BipD: an invasion protein associated with the type III secretion system of Burkholderia pseudomallei. J. Mol. Biol., 363: 125-136.
  7. Coates, L., Erskine, P.T., Mall, S., Gill, R., Wood, S.P., Myles, D.A.A. and Cooper, J.B. (2006) X-ray, neutron and NMR studies of the catalytic mechanism of aspartic proteinases. Eur. Biophys. J., 35: 559-566.
  8. Erskine, P.T., Beaven, G.D.E., Hagan, R., Findlow, I.S., Werner, J.M., Wood, S.P., Vernon, J., Giese, K.P., Fox, G. and Cooper, J.B. (2006) Structure of the neuronal protein calexcitin suggests a mode of interaction in signalling pathways of learning and memory. J. Mol. Biol., 357: 1536-1547.
  9. Williams, P., Coates, L., Mohammed, F., Gill, R., Erskine, P., Bourgeois, D., Wood, S.P., Anthony, C. and Cooper, J.B. (2006) The 1.6 Å X-ray structure of the unusual c-type cytochrome, cytochrome cL, from the methylotrophic bacterium Methylobacterium extorquens. J. Mol. Biol., 357: 151-162.
  10. Gill, R., Mohammed, F., Badyal, R., Coates, L., Erskine, P., Thompson, D., Cooper, J., Gore, M. and Wood, S. (2005) High resolution structure of myo-inositol monophosphatase, the putative target of lithium therapy. Acta Cryst., D61: 545-555.
  11. Dunn, G., Montgomery, M.G., Mohammed, F., Coker, A., Cooper, J.B., Robertson, T., Garcia, J.-L., T.D.H. Bugg and Wood, S.P. (2005) The structure of the C-C bond hydrolase MhpC provides insights into its catalytic mechanism. J. Molec. Biol., 346: 253-265.

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