Master of Science in Algal Biotechnology (University of Malaya,
Bachelor of Applied Science in Conservation and Management of
Biodiversity (University College of Science and Technology Malaysia (KUSTEM),
Vaccine production in Chlamydomonas reinhardtii
Infectious diseases represent a continuously growing problem, adversely affecting human health and the agriculture, farming and poultry industries. Vaccines that are currently used for the prevention and spread of diseases have several drawbacks, such as high cost of production and delivery; and the production is often accompanied by endotoxins, thereby raising some safety concerns. Therefore, there is an urgent need to produce effective, cheaper and safer vaccines. The microalga Chlamydomonas reinhardtii could be an ideal candidate for the production of recombinant proteins such as vaccines. As well as exhibiting rapid growth and high protein yields, C. reinhardtii is generally regarded as safe, able to be genetically modified, capable of rapid scale up, capable of appropriated post-translational modifications and able to produce, fold and assemble complex proteins. Hence, the main goal of this research is to investigate the production of protein vaccines in C. reinhardtii. In order to achieve this goal, the microalga will be genetically modified with a gene encoding a vaccine. This will then be followed by genomic and proteomic analysis to understand the integration and expression of the gene within the microalga.