Dr Sioban SenGupta is Deputy Director of UCL Centre for PGD and heads molecular based diagnosis in PGD. She is a member of the ESHRE PGD Consortium Steering Committee. She is a principal investigator for research into preimplantation genetics and is the Institute Graduate Tutor (Research Students).
Sioban graduated from UCL in 1988 with a BSc in Microbiology / Genetics and completed her PhD at the Galton Laboratory, UCL in 1993. Between 1994 and 2003 Sioban was a Research Fellow in the Department of Surgery, UCL working on the genetics of the inherited cancer predisposition. In 2003 she joined the PGD team at UCL as a lecturer to oversee PGD for monogenic disorders.
Training and education
Sioban co- organises the biannual PGD workshop and has developed an extended hands on training programme in PGD. She is the lead for two genetics modules in the MSc in Prenatal Genetics and Medicine. She has supervised a number of PhD students and as the Graduate Tutor for Research students oversees the progress of all PhD and MD(Res) in the IfWH.
Sioban’s research interests are based on the changes that arise in gene expression from fertilisation to the blastocyst stage of human preimplantation development. She is studying DNA repair in early embryos through the analysis of mRNA, microRNA and DNA methylation profiles of these genes in human oocytes and blastocysts and also using functional assays. Part of her research involves the development of new protocols that can be applied clinically in PGD.
Publications and books
SenGupta SB. Van der Luijt RB, Bowles LV, Meera Khan P, Delhanty JDA . Somatic mutation of APC gene in desmoid tumour in familal adenomatous polyposis. The Lancet 1993; 342: 552-553.
Gayther SA, Wells D, SenGupta SB, Chapman P, Neale K, Tsioupra K, Delhanty JDA. Regionally clustered APC mutations are associated with a severe phenotype and occur at a high frequency in new mutation cases of adenomatous polyposis coli. Human Molecular Genetics. 1994; 3: 53-56
SenGupta SB, Yiu C-Y, Boulos PB, DeSilva M, Sams VR, Delhanty JDA. Genetic instability in patients with metachronous coloretal cancers. British Journal of Surgery 1997; 84: 996-1000.
Fajobi O, Yiu C-Y, SenGupta SB, Boulos PB. Metachronous colorectal cancers. British Journal of Surgery, 1998;85: 879-901
SenGupta SB, Pearson TE, Yiu C-Y and Boulos PB. Evaluation of colonoscopic sized biopsies for microsatellite instability and adenomatous polyposis coli (APC) variants. Colorectal Disease,2000; 2:304-308
Lawes DA, SenGupta SB, Boulos PB. Pathogenesis and clinical management of hereditary non-polyposis colorectal cancer. British Journal of Surgery, 2002; 89: 1357-1369
Lawes DA, SenGupta SB, Boulos PB.The clinical importance and prognostic implications of microsatellite instability in sporadic cancers. European Journal of Surgical Oncology, 2003; 29(3): 201-212
Lawes DA, Pearson T, SenGupta S and Boulos PB. The role of MLH1, MSH2 and MSH6 in the development of multiple colorectal cancers. British Journal of Cancer, 2005;93(4), 472-477
Harper JC, Boelaert K, Geraedts J, Harton G, Kearns WG, Moutou C, Muntjewerff N, Repping S, SenGupta S, Scriven PN, Traeger-Synodinos J, Vesela K, Wilton L, Sermon KD. ESHRE PGD Consortium data collection V: Cycles from January to December 2002 with pregnancy follow-up to October 2003. Hum Reprod. 2006 Jan;21(1):3-21
Lawes DA, Pearson T, SenGupta S and Boulos PB. Is MSI-H of value in predicting the development of metachronous cancer? European Journal of Cancer. 2006 Mar;42(4):473-6
Sermon, K.D, Michiels, A, Harton, G, Moutou, C, Repping, S, Scriven, P.N, SenGupta, S,Traeger-Synodinos, J, Vesela, K, Viville, S, Wilton, L, Harper, J.C (2007) ESHRE PGD Consortium data collection VI: Cycles from January to December 2003 with pregnancy follow-up to October 2004, Hum Reprod. 22(2):323-36
Kakourou, G, Dhanjal, S, Daphnis, D, Doshi, A, Nuttall, S, Gotts, S, Serhal, P, Delhanty, J, Harper, JC, and SenGupta, S (2007) Preimplantation genetic diagnosis for myotonic dystrophy type 1: detection of cross-over between the gene and the linked marker APOC2. Prenatal Diagnosis, 27(2):111-116
Jaroudi S, and SenGupta, S (2007) DNA repair in mammalian embryos, Reviews in Mutation Research, 635(1):53-77
Dhanjal, S, Kakourou, G, Mamas, T, Saleh, ,N, Doshi, A, Gotts, S, Nuttall, S, Fordham, K, Serhal, P, Delhanty, J, Harper, JC and SenGupta, S (2007) Preimplantation Genetic Diagnosis for Retinoblastoma predisposition, Br. J. Ophthalmol.91:1090-1091.
Kakourou G, Dhanjal S, Mamas T, Gotts S, Doshi A, Fordham K, Serhal P, Ranieri DM, Delhanty JDA, Harper JC and SenGupta SB. (2008). Preimplantation genetic diagnosis for myotonic dystrophy type 1 in the UK. Neuromuscular Disorders 18: 131–136
Harper JC, de Die-Smulders C, Goossens V, Harton G, Moutou C, Repping S, Scriven PN, SenGupta S, Traeger-Synodinos J, Van Rij MC, Viville S, Wilton L, Sermon KD. (2008) ESHRE PGD consortium data collection VII: cycles from January to December 2004 with pregnancy follow-up to October 2005. Human Reproduction Vol.23, No.4 pp. 741–755
Harper, JC, Sermon, K, Geraedts, J, Vesela, K, Harton, G, Thornhill, A, Pehlivan, T, Fiorentino, F, SenGupta, S, de Die-Smulders, C, Magli, C, Moutou, C and Wilton L (2008) What next for Preimplantation Genetic Screening (PGS)? Human Reproduction Vol.23, No.3, 478–480
18) Jaroudi S, Kakourou G, Cawood S, Doshi A, Ranieri DM, Serhal , Joyce C. Harper JC, SenGupta SB. (2009). Expression profiling of DNA repair genes in human oocytes and blastocysts using microarrays Hum Reprod. 2009 Oct;24(10):2649-55
Glentis S, SenGupta S, Thornhill A, Wang R, Craft I, Harper, JC. Molecular comparison of single cell MDA products derived from different cell types. Reprod Biomed Online. 2009 Jul;19(1):89-98
Harper J, Coonen E, De Rycke M, Fiorentino F, Geraedts J, Goossens V, Harton G,Moutou C, Pehlivan Budak T, Renwick P, Sengupta S, Traeger-Synodinos J, Vesela K. What next for preimplantation genetic screening (PGS)? A position statement from the ESHRE PGD Consortium steering committee. Hum Reprod. 2010 Apr;25(4):821-3. Epub 2010 Feb 2
Harper JC, SenGupta S, Vesela K, Thornhill A, Dequeler E, Coonen E, and Morris MA. Accreditation of the PGD laboratory. Hum Reprod. 2010 Apr;25(4):1051-65. Epub 2010 Jan 23
Kakourou G, Dhanjal S, Mamas T, Serhal, Delhanty JD, SenGupta SB Modification of the triplet repeat primed PCR (TP-PCR) method for detection of the CTG repeat expansion in myotonic dystrophy type 1 (DM1): application in preimplantation genetic diagnosis. Fertil Steril. 2010 Oct;94(5):1674-9. Epub 2010 Feb 19
Harton GL, De Rycke M, Fiorentino F, Moutou C, SenGupta S, Traeger-Synodinos J, Harper JC; European Society for Human Reproduction and Embryology (ESHRE) PGD Consortium. ESHRE PGD consortium best practice guidelines for amplification-based PGD. Hum Reprod. 2011 Jan;26(1):33-40. Epub 2010 Oct 21. PubMed PMID: 20966462.
Xanthopoulou L, Delhanty JD, Mania A, Mamas T, Serhal P, SenGupta SB, Mantzouratou A. The nature and origin of binucleate cells in human preimplantation embryos: relevance to placental mesenchymal dysplasia. Reprod Biomed Online. 2011 Apr;22(4):362-70. Epub 2011 Jan 20. PubMed PMID: 21324746.
Harper JC, SenGupta SB. Preimplantation genetic diagnosis: State of the ART 2011. Hum Genet. 2011 Jul 12. [Epub ahead of print] PubMed PMID: 21748341.
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