Cellular mechanisms of virus entry and assembly
Virus cell biology
HIV particle budding from an infected HeLa cell. Small gold particles label the Gag structural protein p24/p55; the large gold particles label Env. Scale bar = 100 nm. A. Pelchen-Matthews
We aim to understand aspects of the cellular and molecular mechanisms that underlie the replication of mammalian viruses, specifically how viruses enter target cells, and how new virus particles are assembled and released from infected cells. We currently use HIV-1 and the related simian viruses as models where detailed understanding of cell biology may have application in the development of novel inhibitors or treatments.
Virus entry and productive infection generally require the...